Replenishes deficiency of magnesium.
Magnesium is a vital element that is found in all tissues of the body and is essential for normal functioning of cells. Most reactions involved in metabolism, regulation of nerve impulse transmission and muscle contraction has spasmolytic, antiarrhythmic and antiplatelet effect.
Organism receives magnesium with food. Lack equipoise vs deca of magnesium in the body can be observed in violation of the diet (diet) or by increasing the demand for magnesium (for increased physical and mental load, stress, pregnancy, use of diuretics).
Pyridoxine (vitamin B 6 ) is involved in many metabolic processes in the regulation of metabolism nervous system. Vitamin B 6 enhances the absorption of magnesium from the gastrointestinal tract and its penetration into the cells.
The magnesium content in serum:
- from 12 to 17 mg / l (0.5-0.7 mmol / l) speaks of moderate magnesium deficiency.
- below 12 mg / l (0.5 mmol / l) speaks about the heavy magnesium deficiency.Pharmacokinetics
magnesium absorption in the gastrointestinal tract is 50% of the oral dose received. Write mainly by the kidneys. In the kidney after glomerular filtration 70% of the magnesium present in the plasma, it is reabsorbed by the renal tubules in the ratio 95% – 97%.
Established magnesium deficiency, isolated or associated with other deficient states.
Hypersensitivity to the drug, pronounced renal insufficiency (creatinine clearance less than 30 ml / min), phenylketonuria. Children age – up to 6 years. Precautions: with moderate renal impairment, as there is a risk of gipermagniemii.
Pregnancy and breast-feeding
Pregnancy: Clinical experience has not revealed foetotoxic or causes fetal malformations action. Equipoise vs deca can be used during pregnancy only on the testimony of a doctor. Lactation: Magnesium passes into breast milk. Should be avoided during lactation and breastfeeding.
Dosing and Administration
Before taking this medication, you should consult with your doctor. Adults are recommended to take 6-8 tablets a day. Children older than 6 years (weighing more than 20 kg) 4-6 tablets per day. The daily dose should be divided into 2-3 doses, taken with meals, washed down with a glass of water.
Treatment should be discontinued after the normalization of blood magnesium concentration.
From the digestive tract: abdominal pain, constipation, nausea, vomiting, flatulence. Allergic reactions: possible allergic reaction to the components of the preparation.
In normal renal function receiving an oral magnesium does not cause toxic reactions. Magnesium poisoning may develop in patients with renal insufficiency. Toxic effects are largely dependent on the magnesium content in the blood serum. Overdose symptoms: drop in blood pressure, nausea, vomiting, slowing of reflexes, anuria, respiratory depression, coma, heart failure. Treatment: rehydration, forced diuresis. In renal failure required hemodialysis or peritoneal dialysis.
Interaction with other drugs
- The simultaneous use of preparations containing phosphate or calcium salts, can significantly reduce the magnesium absorption in the gastrointestinal tract.
- magnesium drugs reduce the absorption of tetracycline, it is recommended to share their equipoise vs deca drug three-hour intervals.
- Magnesium reduces the effect of oral thrombolytic agents, reduces the absorption of iron.
- Vitamin B 6 inhibits the activity of levodopa.
Information for diabetics: tablets contain sucrose as an excipient.
In the case of concomitant calcium deficiency, magnesium deficiency should be corrected before you start taking calcium supplements.
For prolonged use of laxatives, alcohol, intense physical and mental stress need for magnesium increases, may lead to deficiency in magnesium.