Magnesium is a macronutrient required for many energy processes involved in the metabolism of proteins, fats, carbohydrates and nucleic acids. Magnesium is involved in the process of neuromuscular excitation, inhibiting equipoise for sale neuromuscular transmission. Of particular interest is magnesium as a natural physiological calcium antagonist. Magnesium controls the normal functioning of the myocardial cells; involved in the regulation of myocardial contractility. In stressful situations, displayed an increased amount of free ionized magnesium, and therefore, an additional amount of magnesium enhances resistance to stress.
Magnesium deficiency leads to neuromuscular disorders (motor and sensory hyperexcitability, convulsions, paresthesia), psychological changes (depression, confusion and hallucinations), cardio – vascular disease (ventricular arrhythmia, tachycardia, increased sensitivity to cardiac glycosides). Magnesium deficiency during pregnancy increases the chance of toxemia and premature birth. Orotic acid salts are involved in metabolism. Orotic acid addition salts of magnesium needed to fix on the ATP in the cell and displays its action.
Absorbed about 35 – 40% of the dose. Hypomagnesemia stimulates the absorption of magnesium ions. The presence of salts of orotic acid, contribute to improving the absorption of magnesium. Magnesium is excreted by the kidneys, excretion is reduced by magnesium deficiency and increased by his excess.
In the complex treatment and as prevention of myocardial infarction, treatment of angina pectoris, congestive heart failure, cardiac arrhythmias caused by magnesium deficiency, spastic states – pain and muscle spasms (including vasoconstriction), atherosclerosis, arteries, lipid metabolism disorders.
Hypersensitivity to the drug, urolithiasis, renal dysfunction, susceptibility to the formation of calcium-magnesium-ammonium-phosphate stones, liver cirrhosis with ascites.
The drug contains lactose, therefore it should not be used in patients with lactose intolerance, lactase deficiency or glucose-galactose malabsorption.
Children under 18 years old.
Pregnancy and lactation
Perhaps the use of the drug during pregnancy and lactation (breastfeeding) on the testimony, as these periods need for magnesium increases significantly. If its content is not balanced, it can lead to serious complications, including miscarriage. Use of the drug during pregnancy and lactation is possible if the potential benefit to the mother outweighs the potential risk to the fetus and child.
Dosing and Administration
The tablets should be taken orally before meals with a little liquid. Assign 2 tablets 3 times a day for 7 days, then – 1 tablet 2-3 times daily. Course duration of at least 4-6 weeks. If necessary Magnerot ® , can be used for a long time.
At night leg cramps it is recommended to take 2-3 tablets evenings.
From the gastrointestinal equipoise for sale tract: an unstable chair, and diarrhea, which usually pass on their own at lower doses of the drug; allergic reactions.
- If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, inform your doctor.
In normal kidney function magnesium intake does not cause toxic reactions.Magnesium poisoning may develop in patients with renal insufficiency.Toxic effects are largely dependent on the concentration of magnesium in the blood serum.Symptoms: decrease in blood pressure, nausea, vomiting, depression, diminished reflexes, respiratory depression, coma, cardiac arrest, anurichesky syndrome.Treatment: rehydration, forced diuresis.In renal failure required hemodialysis or peritoneal dialysis.
Interaction with other drugs when taken concomitantly with drugs magnesium iron preparations, sodium fluoride and tetracyclines may decrease the absorption of the latter. Therefore, you should take drugs with 2-3 hours interval. Oral contraceptives, diuretics, muscle relaxants, glucocorticoids, insulin, reduce the effect of the drug.
Effects on ability to drive vehicles and operate machinery:
The product does not affect the ability to drive vehicles and other activities that require high concentration and speed of psychomotor reactions. Magnerot ® can be used for a long time.
It will be appreciated that by magnesium deficiency in the body may cause gastrointestinal disease; food consumption with a reduced content of magnesium; exercise (due to sweating); alcoholism (due to a decrease in bone resorption magnesium renal equipoise for sale tubules and strengthen the removal of magnesium ions from the body); taking certain drugs (cardiac glycosides, aminogliklozidnye antibiotics, oral contraceptives, diuretics, laxatives, corticosteroids); conditions requiring high magnesium intake (lack of exercise, stress, pregnancy and lactation); prolonged exposure to the sun.